H．史密斯采集的中国紫草科植物

自H．Smith在二十,三十年代从我国采集的紫草科标本中鉴定出15属,36种,4变种,均属紫草亚科,其中包括附地菜属一新种,其中,这批标本本来应该包括更多的新种,如Johnston在1928年及以后描述的Microula rockii Johnst.,Onosma mertensioides Johnst.,O.adenopus Johnst.,Trionotis floribunda Johnst.,Kitagawa在六十年代描述的Lappula shanhsiensis Kitag.,本文作者和王庆瑞在八十年代描述的Microula pseudotrichocarpa W.T.Wang,M.turbinata W.T.Wang,M.turbinata W.T.Wang,M.floribunda W.T.Wang,Trigontis longipes W.T.Wang,T.corispermoides C.J.wang。只是由于这批柴草科标本未得到及时鉴定,才推迟了这10个种的发表。     

An immune response profile model for immunogenicity quantitation

We propose an analytical model, which can simultaneously depict many fundamental characteristics of the immunogenicity of various vaccines. This model, the Immune Response (IR) profile, conveniently expresses the mathematical relation between pre- and post-vaccination titers. A vaccine's IR profile is antigen-specific, dose-dependent and post-vaccination interval-dependent. The maximal capability for serological response to a vaccine can be determined using this model irrespective of the dose administered, the post-vaccination assay interval, or the live or killed state of the vaccine. The IR profile obtained from analysis of booster vaccine responses in a limited number of seropositive study subjects can be used to predict maximal antibody titers which are expected after vaccination and can predict the geometric mean post-vaccination antibody titer of a cohort of subjects undergoing primary immunization. Using this model, it is anticipated that the immunoregulation implied by the IR profile may also prove to be correlated with cellular subpopulations and idiotypic antibody functions. Although derived from influenza vaccines analyses, the model successfully describes immune response characteristics following natural infection with malaria and following diphtheria and rubella vaccine administration.     

Sources of Thought Two 19th-century Chronobiologists: Thomas Laycock and Edward Smith

This article describes the works of two 19th-century chronobiologists. Thomas Laycock (1812-1876), who held the Chair of Medicine in Edinburgh from 1855-1876, published a series of seven articles in Lancet, all dedicated to periodicities in “vital phenomena.” Laycock considered the understanding of periodicities essential for the advancement of the treatment of diseases. Edward Smith (1818-1874) was a pioneer in experimental chronobiology. In his 1861 book entitled: Health and disease as influenced by daily, seasonal and other cyclical changes in the human, Smith summarized a large number of experiments in which he investigated the occurrence of periodicities in pulse rate, urine flow, urea excretion, and respiration. From his experimental results and those of others, Smith drew practical conclusions regarding patients' care, the timing of drug administration, and the design of night work.     

大胡蜂蜂毒中多肽和蛋白质结构和功能的多样性

为证明大胡蜂Vespa magnifica(Smith)蜂毒具有较大的药用开发价值,本研究采用超高效液相色谱-质谱和电泳技术对其多肽和蛋白质的分布进行分析,发现其蛋白质的相对分子质量主要分布在17~45kDa范围内。蜂毒多肽类物质的相对分子质量呈"单峰"式分布,61%在500~3000Da范围内,为大胡蜂蜂毒中多肽含量最为丰富的部分。通过牛津杯法对蜂毒的抑菌活性进行研究,且以HepG2人肝癌细胞及B16黑色素瘤细胞为研究对象,用MTT法检测蜂毒的细胞毒性活性,证明其具有良好的抑菌作用和细胞毒活性,其结果与已报道的其他蜂类既有相似性又存在具体差异,展示了大胡蜂蜂毒的分子多样性,为后续该毒素的物质基础研究及药用价值开发提供参考。     

Studies on chlorophyll biosynthesis and other things

Our research on chlorophyll biosynthesis, over a period of approximately twenty years, has been described, emphasizing those areas in which our laboratory made significant and timely contributions. References to some of our most important articles are included. Portions of the chlorophyll biosynthetic pathway, in which our own laboratory was not involved, for example, the reduction of protochlorophyllide to chlorophyllide and the phytylation of the latter to yield chlorophyll a, have not been covered in this article. Those events which preceded my involvement with chlorophyll biosynthesis, but which contributed to the formation of my own scientific personality, are mentioned briefly in the Introduction. My non-scientific avocations have been included at the request of the reviewers and Govindjee.     

Strategic analysis in evolutionary genetics and the theory of games

This paper is written in memory of John Maynard Smith. In a brief survey it discusses essential aspects of how game theory in biology relates to its counterpart in economics, the major transition in game theory initiated by Maynard Smith, the discrepancies between genetic and phenotypic models in evolutionary biology, and a balanced way of reconciling these models. In addition, the paper discusses modern problems in understanding games at the genetic level using the examples of conflict between endosymbionts and their hosts, and the molecular interactions between parasites and the mammalian immune system.     

Geothermal bryophyte habitats in the South Sandwich Islands,maritime Antarctic

Question: How does geothermal activity influence terrestrial plant colonization, species composition and community development in the Antarctic? Location: South Sandwich Islands, maritime Antarctic. Methods: Bryophytes were documented during a biological survey of the archipelago in January and February 1997. Particular attention was given to sites under current or recent influence of geothermal activity. Temperature profiles obtained across defined areas of activity on several islands were linked with the presence of specific bryophytes. Results: Greatest bryophyte richness was associated with geothermally influenced ground. Of 35 moss and nine liverwort species recorded, only four mosses were never associated with heated ground, while eight of the liverworts and 50% of the mosses were found only on actively or recently heated ground. Some species occur in unheated sites elsewhere in the maritime Antarctic, but were absent from such habitats on the South Sandwich Islands. Several species occurred in distinct zones around fumaroles. Maximum temperatures recorded within the upper 0.5 cm of the vegetation surface were 40 ‐ 47 °C, with only Campylopus introflexus tolerating such temperatures. Maximum temperatures 2.5 or 5 cm below the vegetation surface of this moss reached 75 °C. Other bryophytes regularly present in zoned vegetation included the mosses Dicranella hookeri, Sanionia georgico‐uncinata, Pohlia nutans and Notoligotrichum trichodon, and the liverworts Cryptochila grandiflora and Marchantia berteroana. Surface temperatures of 25 ‐ 35 °C and subsurface temperatures of 50 ‐ 60 °C were recorded in these species. Conclusions: These exceptional plant communities illustrate the transport of viable propagules into the Antarctic. Individually ephemeral in nature, the longer term existence of geothermal habitats on islands along the Scotia Arc may have provided refugia during periods of glacial expansion, facilitating subsequent recolonization of Antarctic terrestrial habitats.     

人工栽培与野生种抱茎獐牙菜矿物元素和氨基酸对比分析

抱茎獐牙菜又称藏茵陈,是藏药中常用草药,广泛应用于肝胆疾病的治疗。近年来,为满足日益增加的需求量,发展了人工栽培抱茎獐牙菜,研究比较人工栽培与野生抱茎獐牙菜之间的各种成分含量,对人工栽培抱茎獐牙菜替代野生抱茎獐牙菜用药有重要意义。本文对人工栽培及野生抱茎獐牙菜的矿物元素及氨基酸进行测定比较发现,人工栽培抱茎獐牙菜的矿物元素绝大多数比野生抱茎獐牙菜含量高,人工栽培抱茎獐牙菜氨基酸大多比野生抱茎獐牙菜含量高。